The statistics of antimicrobial resistance in Nigeria reveal an escalating public health challenge that threatens effective treatment of infections. Recent reports show that over 70% of bacterial infections are resistant to commonly prescribed antibiotics, making treatment more difficult and expensive. Factors driving this include the misuse of antibiotics, poor infection control practices, and lack of updated surveillance data. Hospitals are seeing rising cases of multidrug-resistant organisms such as Escherichia coli and Staphylococcus aureus. Addressing this crisis requires coordinated strategies, public awareness, and stricter regulation of antibiotic sales to curb the spread of resistance and protect the country’s health system.