Ivermectin cream for humans, traditionally used for conditions like rosacea, has also been explored for its potential benefits in treating acne. Ivermectin has anti-inflammatory effects that help decrease the redness and swelling associated with acne. Gently wash your face with a mild cleanser and pat dry before applying the cream. Apply a pea-sized amount of ivermectin cream to the affected areas. Always use ivermectin cream under the guidance of a healthcare provider, particularly if you have other skin conditions or are using other medications.